July 2, 2024

Douglas Murphy-Chutorian
Chief Executive Officer
Semler Scientific, Inc.
2340-2348 Walsh Avenue, Suite 2344
Santa Clara, CA 95051

       Re: Semler Scientific, Inc.
           Registration Statement on Form S-3
           Filed June 6, 2024
           File No. 333-280013
Dear Douglas Murphy-Chutorian:

     We have conducted a limited review of your registration statement and have
the following
comments.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe a comment applies to your facts
and circumstances
or do not believe an amendment is appropriate, please tell us why in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to this letter, we may have additional comments.

Registration Statement on Form S-3
Cover Page

1.     It appears that the price of your common stock has fluctuated
significantly in the last
       several months. Please revise your disclosure to address price
volatility, potential causes
       of such volatility, if known, and add a separately captioned risk factor
to describe the risk
       to investors. In addition, on the prospectus cover page, disclose the
following:
           describe the recent price volatility in your stock and briefly
disclose any known risks
            of investing in your stock under these circumstances;
           for comparison purposes, disclose the market price of your common
stock prior to the
            recent price volatility in your stock; and
           describe any recent change in your financial condition or results of
operations, such
            as your earnings, revenues or other measure of company value that
is consistent with
            the recent change in your stock price. If no such change to your
financial condition or
            results of operations exists, disclose that fact.
 July 2, 2024
Page 2

Risk Factors, page 2

2.     We note the disclosure on page 7 that you intend to use the net proceeds
from the sale of
       any securities offered under this prospectus primarily for general
corporate purposes,
       including the acquisition of bitcoin, unless otherwise indicated in the
applicable
       prospectus supplement. Please include a separate risk factor here to
disclose that
       proceeds from an offering may be used to purchase additional bitcoin and
describe the
       attendant risks, including the price of bitcoin has been, and will
likely continue to be,
       highly volatile.
Recent Developments
Bitcoin Strategy, page 5

3.     Please prominently disclose that you are not registered as an investment
company under
       the 1940 Act and that shareholders do not have the protections
associated with ownership
       of shares in a registered investment company or the protections afforded
by the
       Commodities Exchange Act.
4.     Please briefly explain the relevance of the comparisons to gold given
you previously held
       cash in a variety of non-interest bearing bank accounts, interest
bearing money markets,
       and treasury bills. Additionally, provide the basis for your beliefs
that bitcoin    has the
       potential to generate outsize returns    and its increasing acceptance
as    digital gold.
       Balance this discussion by disclosing that bitcoin is a highly volatile
asset and quantity the
       range that bitcoin has traded in the last twelve months.
5.     Refer to exhibit 99.1 to the Form 8-K filed June 6, 2024. We note the
use of the term
          unregulated    when referring to certain bitcoin trading venues.
Please revise to qualify
       your use of this term by clarifying that these venues may be subject to
regulation in a
       relevant jurisdiction but may not be complying.
6.     Please disclose your policies governing when you exchange your cash for
bitcoin and
       when you monetize your bitcoin. In addition, disclose whether you have
policies
       governing the percentage of your treasury holdings that will be bitcoin.
7.     To the extent you intend to hedge your bitcoin exposure, please discuss
your hedging
       strategy. To the extent you do not intend to hedge your bitcoin
exposure, revise the
       bitcoin volatility risk factor to describe the associated risks.
8.     You state that you would become subject to additional counterparty risks
if you pursue
       strategies to create income streams or otherwise generate funds using
your bitcoin
       holdings. Please discuss the strategies you are contemplating, the
factors you will consider
       in determining whether to pursue a particular strategy, and describe the
associated risks.
9.     Please disclose the identity of your liquidity provider and disclose the
material terms of
       the agreement, including which party is responsible for the costs
associated with transfers
       of bitcoin.
10.    To the extent that future bitcoin purchases will be executed using a
time-weighted average
       price over a pre-arranged time period, please revise your disclosure as
follows:
           Describe the material aspects of methodology used to calculate the
time-weighted
           average price of bitcoin.
           Disclose the pre-arranged time periods for the transfers of bitcoin
and describe how
 July 2, 2024
Page 3

           the bitcoin is transferred.
             To the extent that the average price is calculated by referencing
crypto asset trading
           platforms, identify the trading platforms, where each trading
platform is located and
           how it is licensed or regulated, and the criteria and process for
selecting particular
           trading platforms.
11.    You state that your bitcoins are held in cold storage with a third-party
provider. Please
       identify the third-party custodian and file the custody agreement as an
exhibit to the
       registration statement. Also disclose and discuss the material aspects
of the bitcoin
       custody agreement, including the following:
           Describe how the custodian stores the private keys, including
whether they will be
           commingled with assets of other customers and the geographic area
where they will
           be stored.
           Identify who will have access to the private key information and
disclose whether any
           entity will be responsible for verifying the existence of the
bitcoin.
           Disclose whether the custodian carries insurance for any losses of
the bitcoin it
           custodies for you. If so, quantify the amount of and character of
the insurance,
           disclose whether the insurance is shared among the custodian   s
customers, and
           describe any limitations on the custodian   s liability.
           Identify and describe the regulatory regimes applicable to the
custodian and
           additional custodians you engage in the future.
           Discuss your plans to engage additional custodians, including how
you will select a
           particular custodian and any policies for allocating your bitcoin
holdings.
12.    You state that    no assurance can be provided that our custodially-held
bitcoin will not
       become part of the custodian   s insolvency estate if one or more of our
custodians enters
       bankruptcy, receivership or similar insolvency proceedings.    Please
add a separate risk
       factor describing the specific risks and illustrate with recent examples
where such an
       event has occurred.
13.    Please disclose your policies related to forks and airdrops. Also
describe the risks
       associated with forks and airdrops in a separate risk factor and
illustrate these risks by
       providing an example, with quantification, of the impact that hard forks
have had on
       crypto assets.
14.    Please describe anti-money laundering (AML), know-your-customer (KML)
and other
       procedures conducted by you and the liquidity provider to mitigate
transaction risk,
       including whether a transaction counterparty is subject to sanctions and
is otherwise in
       compliance with applicable laws and regulations. Also add risk factor
disclosure
       describing the risks of that these due diligence procedures may fail to
prevent transactions
       with a sanctioned entity and the impact if such a transaction occurs.
15.    Please include a specific cross-reference here to your Bitcoin Strategy
Related
       Supplemental Disclosures document, filed as Exhibit 99.1 to your June 6,
2024 Form 8-K.
       Where you describe your new bitcoin strategy, please make appropriate
changes.
Risk Factors, page 5

16.    Please describe any material risks to your business from the possibility
of regulatory
 July 2, 2024
Page 4

       developments related to crypto assets and crypto asset markets. Identify
material pending
       crypto legislation or regulation and describe any material effects it
may have on your
       business, financial condition, and results of operations. Your
discussion should include an
       analysis of the applicability of the Investment Company Act of 1940. We
note some of
       your disclosures in Exhibit 99.1 to the Form 8-K filed June 6, 2024.
17.    Please describe any material financing, liquidity, or other risks you
face related to the
       impact that a crypto asset market disruption may have, directly or
indirectly, on the value
       of the crypto assets you may elect to use as collateral. We note some of
your disclosures
       in Exhibit 99.1 to the Form 8-K filed June 6, 2024.

Exhibits Index, page II-1

18.    The Bitcoin Strategy Related Supplemental Disclosures document appears
directly related
       to the offering and the disclosures in your registration statement.
Please include as an
       exhibit to your registration statement your Bitcoin Strategy Related
Supplemental
       Disclosures document.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Benjamin Richie at 202-551-7857 or Lauren Nguyen at
202-551-3642
with any other questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Industrial Applications and
                                                            Services
cc:   Marianne Sarrazin, Esq.